Altered contralateral sensorimotor system organization after experimental hemispherectomy: a structural and functional connectivity study.

ABSTRACT: Hemispherectomy is often followed by remarkable recovery of cognitive and motor functions. This reflects plastic capacities of the remaining hemisphere, involving large-scale structural and functional adaptations. Better understanding of these adaptations may (1) provide new insights in the neuronal configuration and rewiring that underlies sensorimotor outcome restoration, and (2) guide development of rehabilitation strategies to enhance recovery after hemispheric lesioning. We assessed brain structure and function in a hemispherectomy model. With MRI we mapped changes in white matter structural integrity and gray matter functional connectivity in eight hemispherectomized rats, compared with 12 controls. Behavioral testing involved sensorimotor performance scoring. Diffusion tensor imagin

SUBMITTER: Otte WM 

PROVIDER: S-EPMC4527994 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature