Reliability of CT perfusion-derived CBF in relation to hemodynamic compromise in patients with cerebrovascular steno-occlusive disease: a comparative study with 15O PET.

ABSTRACT: In the bolus tracking technique with computed tomography (CT) or magnetic resonance imaging, cerebral blood flow (CBF) is computed from deconvolution analysis, but its accuracy is unclear. To evaluate the reliability of CT perfusion (CTP)-derived CBF, we examined 27 patients with symptomatic or asymptomatic unilateral cerebrovascular steno-occlusive disease. Results from three deconvolution algorithms, standard singular value decomposition (sSVD), delay-corrected SVD (dSVD), and block-circulant SVD (cSVD), were compared with (15)O positron emission tomography (PET) as a reference standard. To investigate CBF errors associated with the deconvolution analysis, differences in lesion-to-normal CBF ratios between PET and CTP were correlated with prolongation of arterial-tissue delay (ATD) and m

SUBMITTER: Ibaraki M 

PROVIDER: S-EPMC4528001 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature