Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study.

ABSTRACT:

Background

It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients.

Objective

This study was to evaluate the effect of the prebiotic xylooligosaccharide (XOS) on the gut microbiota in both healthy and prediabetic (Pre-DM) subjects, as well as impaired glucose tolerance (IGT) in Pre-DM.

Subjects/methods

Pre-DM (n = 13) or healthy (n = 16) subjects were randomized to receive 2 g/day XOS or placebo for 8-weeks. In Pre-DM subjects, body composition and oral glucose tolerance test (OGTT) was done at baseline and week 8. Stool from Pre-DM and healthy subjects at baseline and week 8 was analyzed for gut microbiota characterization using Illumina MiSeq sequencing.

Results

We identified 40 Pre-DM associated bacterial taxa. Among

SUBMITTER: Yang J 

PROVIDER: S-EPMC4528259 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature