Using Bayesian Multilevel Whole Genome Regression Models for Partial Pooling of Training Sets in Genomic Prediction.

ABSTRACT: Training set size is an important determinant of genomic prediction accuracy. Plant breeding programs are characterized by a high degree of structuring, particularly into populations. This hampers the establishment of large training sets for each population. Pooling populations increases training set size but ignores unique genetic characteristics of each. A possible solution is partial pooling with multilevel models, which allows estimating population-specific marker effects while still leveraging information across populations. We developed a Bayesian multilevel whole-genome regression model and compared its performance with that of the popular BayesA model applied to each population separately (no pooling) and to the joined data set (complete pooling). As an example, we analyzed a wide

SUBMITTER: Technow F 

PROVIDER: S-EPMC4528317 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature