Dynamics of immunoglobulin sequence diversity in HIV-1 infected individuals.

ABSTRACT: Advances in immunoglobulin (Ig) sequencing technology are leading to new perspectives on immune system dynamics. Much research in this nascent field has focused on resolving immune responses to viral infection. However, the dynamics of B-cell diversity in early HIV infection, and in response to anti-retroviral therapy, are still poorly understood. Here, we investigate these dynamics through bulk Ig sequencing of samples collected over 2 years from a group of eight HIV-1 infected patients, five of whom received anti-retroviral therapy during the first half of the study period. We applied previously published methods for visualizing and quantifying B-cell sequence diversity, including the Gini index, and compared their efficacy to alternative measures. While we found significantly greater cl

SUBMITTER: Hoehn KB 

PROVIDER: S-EPMC4528418 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature