An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting.

ABSTRACT: Excessive migration and proliferation of smooth muscle cells (SMCs) has been observed as a major factor contributing to the development of in-stent restenosis after coronary stenting. Building upon the results from in vivo experiments, we formulated a hypothesis that the speed of the initial tissue re-growth response is determined by the early migration of SMCs from the injured intima. To test this hypothesis, a cellular Potts model of the stented artery is developed where stent struts were deployed at different depths into the tissue. An extreme scenario with a ruptured internal elastic lamina was also considered to study the role of severe injury in tissue re-growth. Based on the outcomes, we hypothesize that a deeper stent deployment results in on average larger fenestrae in the elastic

SUBMITTER: Tahir H 

PROVIDER: S-EPMC4528603 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature