A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues.

ABSTRACT:

Background

The transcription factor p63 belongs to the p53/p63/p73 family and plays key functional roles during normal epithelial development and differentiation and in pathological states such as squamous cell carcinomas. The human TP63 gene, located on chromosome 3q28 is driven by two promoters that generate the full-length transactivating (TA) and N-terminal truncated (ΔN) isoforms. Furthermore alternative splicing at the C-terminus gives rise to additional α, β, γ and likely several other minor variants. Teasing out the expression and biological function of each p63 variant has been both the focus of, and a cause for contention in the p63 field.

Results

Here we have taken advantage of a burgeoning RNA-Seq based genomic data-sets to examine the global expression profiles

SUBMITTER: Sethi I 

PROVIDER: S-EPMC4528692 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature