Differential effects of conductances on the phase resetting curve of a bursting neuronal oscillator.

ABSTRACT: The intrinsically oscillating neurons in the crustacean pyloric circuit have membrane conductances that influence their spontaneous activity patterns and responses to synaptic activity. The relationship between the magnitudes of these membrane conductances and the response of the oscillating neurons to synaptic input has not yet been fully or systematically explored. We examined this relationship using the phase resetting curve (PRC), which summarizes the change in the cycle period of a neuronal oscillator as a function of the input's timing within the oscillation. We first utilized a large database of single-compartment model neurons to determine the effect of individual membrane conductances on PRC shape; we found that the effects vary across conductance space, but on average, the hyperp

SUBMITTER: Soofi W 

PROVIDER: S-EPMC4528914 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature