Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir.

ABSTRACT:

Background

HCV-TARGET is a longitudinal observational study of chronic hepatitis C virus (HCV) patients treated with direct-acting anti-viral agents (DAAs) in a US consortium of 90 academic and community medical centres.

Aim

To assess utilisation of response-guided therapy (RGT) and sustained virological response (SVR) of a large cohort of patients.

Methods

Patients received peginterferon (PEG-IFN), ribavirin and either telaprevir or boceprevir. Demographical, clinical and virological data were collected during treatment and follow-up. RGT and treatment futility stopping rules was assessed at key time points.

Results

Of 2084 patients, 38% had cirrhosis and 56% had received prior treatment for HCV. SVR rates were 31% (95% CI: 24-40) and 50% (95% CI: 44-56) in bo

SUBMITTER: Sterling RK 

PROVIDER: S-EPMC4529024 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature