Ontology highlight
ABSTRACT:
SUBMITTER: Reginensi A
PROVIDER: S-EPMC4529030 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Reginensi Antoine A Hoshi Masato M Boualia Sami Kamel SK Bouchard Maxime M Jain Sanjay S McNeill Helen H
Development (Cambridge, England) 20150801 15
Despite the high occurrence of congenital abnormalities of the lower urinary tract in humans, the molecular, cellular and morphological aspects of their development are still poorly understood. Here, we use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz. Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts, t ...[more]