Discordance between aeroallergen specific serum IgE and skin testing in children younger than 4 years.

ABSTRACT:

Background

Atopic sensitization to aeroallergens in early life has been found to be a strong risk factor for the development of persisting asthma in young children with recurrent wheeze.

Objective

To assess the yield of skin prick test (SPT) compared with allergen specific serum IgE (sIgE) testing at identifying aeroallergen sensitization in atopic children younger than 4 years.

Methods

Concordance between SPT and allergen-specific sIgE testing for 7 common aeroallergens was analyzed in 40 atopic inner-city children 18 to 48 months of age (mean [SD], 36 [9] months) with recurrent wheezing and family history of asthma and/or eczema.

Results

In 80% of children one or more allergen sensitizations would have been missed if only SPT had been performed, and in 38% of

SUBMITTER: de Vos G 

PROVIDER: S-EPMC4529057 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature