Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation.

ABSTRACT: Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.

SUBMITTER: Meyer RA 

PROVIDER: S-EPMC4529071 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature