Functional Connectivity Alterations in Epilepsy from Resting-State Functional MRI.

ABSTRACT: The study of functional brain connectivity alterations induced by neurological disorders and their analysis from resting state functional Magnetic Resonance Imaging (rfMRI) is generally considered to be a challenging task. The main challenge lies in determining and interpreting the large-scale connectivity of brain regions when studying neurological disorders such as epilepsy. We tackle this challenging task by studying the cortical region connectivity using a novel approach for clustering the rfMRI time series signals and by identifying discriminant functional connections using a novel difference statistic measure. The proposed approach is then used in conjunction with the difference statistic to conduct automatic classification experiments for epileptic and healthy subjects using the rfM

SUBMITTER: Rajpoot K 

PROVIDER: S-EPMC4529140 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature