Modularity of Protein Folds as a Tool for Template-Free Modeling of Structures.

ABSTRACT: Predicting the three-dimensional structure of proteins from their amino acid sequences remains a challenging problem in molecular biology. While the current structural coverage of proteins is almost exclusively provided by template-based techniques, the modeling of the rest of the protein sequences increasingly require template-free methods. However, template-free modeling methods are much less reliable and are usually applicable for smaller proteins, leaving much space for improvement. We present here a novel computational method that uses a library of supersecondary structure fragments, known as Smotifs, to model protein structures. The library of Smotifs has saturated over time, providing a theoretical foundation for efficient modeling. The method relies on weak sequence signals from re

SUBMITTER: Vallat B 

PROVIDER: S-EPMC4529212 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature