Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.

ABSTRACT:

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Esophageal adenocarcinomas are associated with a dismal prognosis. Deciphering the evolutionary history of this disease may shed light on therapeutically tractable targets and reveal dynamic mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome sequenced 40 tumor regions from 8 patients with operable esophageal adenocarcinomas, before and after platinum-containing NAC. This revealed the evolutionary genomic landscape of esophageal adenocarcinomas with the presence of heterogeneous driver mutations, parallel evolution, early genome-doubling events, and an association between high intratumor heterogeneity and poor response to NAC. Multiregion sequencing demonstrated a significant reduction in thymine to guanine mutations with

SUBMITTER: Murugaesu N 

PROVIDER: S-EPMC4529488 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature