Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.

ABSTRACT:

Introduction

Induced pluripotent stem cells (iPSCs) have emerged as a promising cell source for immune-compatible cell therapy. Although a variety of somatic cells have been tried for iPSC generation, it is still of great interest to test new cell types, especially those which are hardly obtainable in a normal situation.

Methods

In this study, we generated iPSCs by using the cells originated from intervertebral disc which were removed during a spinal operation after spinal cord injury. We investigated the pluripotency of disc cell-derived iPSCs (diPSCs) and neural differentiation capability as well as therapeutic effect in spinal cord injury.

Results

The diPSCs displayed similar characteristics to human embryonic stem cells and were efficiently differentiated into neu

SUBMITTER: Oh J 

PROVIDER: S-EPMC4529688 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature