Localization of P2X receptor subtypes 2, 3 and 7 in human urinary bladder.

ABSTRACT:

Background

Voiding dysfunctions are a common problem that has a severe negative impact on the quality of life. Today there is a need for new drug targets for these conditions. The role of ATP receptors in bladder physiology has been studied for some time, primarily in animal models. The aim of this work is to investigate the localization of the ATP receptors P2X2, P2X3 and P2X7 and their colocalization with vimentin and actin in the human urinary bladder.

Methods

Immunohistochemical analysis was conducted on full-thickness bladder tissues from fundus and trigonum collected from 15 patients undergoing open radical cystectomy due to chronic cystitis, bladder cancer or locally advanced prostate cancer. Colocalization analyses were performed between the three different P2X subty

SUBMITTER: Svennersten K 

PROVIDER: S-EPMC4529706 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature