A multiobjective approach for identifying protein complexes and studying their association in multiple disorders.

ABSTRACT:

Background

Detecting protein complexes within protein-protein interaction (PPI) networks is a major step toward the analysis of biological processes and pathways. Identification and characterization of protein complexes in PPI network is an ongoing challenge. Several high-throughput experimental techniques provide substantial number of PPIs which are widely utilized for compiling the PPI network of a species.

Results

Here we focus on detecting human protein complexes by developing a multiobjective framework. For this large human PPI network is partitioned into modules which serves as protein complex. For building the objective functions we have utilized topological properties of PPI network and biological properties based on Gene Ontology semantic similarity. The proposed me

SUBMITTER: Bandyopadhyay S 

PROVIDER: S-EPMC4529733 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature