Spatiotemporal relationships between the cell shape and the actomyosin cortex of periodically protruding cells.

ABSTRACT: We investigate the dynamics of cell shape and analyze the actin and myosin distributions of cells exhibiting cortical density traveling waves. These waves propagate by repeated cycles of cortical compression (folding) and dilation (unfolding) that lead to periodic protrusions (oscillations) of the cell boundary. The focus of our detailed analysis is the remarkable periodicity of this phenotype, in which both the overall shape transformation and distribution of actomyosin density are repeated from cycle to cycle even though the characteristics of the shape transformation vary significantly for different regions of the cell. We show, using correlation analysis, that during traveling wave propagation cortical actin and plasma membrane densities are tightly coupled at each point along the cell

SUBMITTER: Driscoll MK 

PROVIDER: S-EPMC4529805 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature