Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.

ABSTRACT:

Background

Traffic-related particulate matter (PM) has been linked to a heightened incidence of asthma and allergic diseases. However, the molecular mechanisms by which PM exposure promotes allergic diseases remain elusive.

Objective

We sought to determine the expression, function, and regulation of pathways involved in promotion of allergic airway inflammation by PM.

Methods

We used gene expression transcriptional profiling, in vitro culture assays, and in vivo murine models of allergic airway inflammation.

Results

We identified components of the Notch pathway, most notably Jagged 1 (Jag1), as targets of PM induction in human monocytes and murine dendritic cells. PM, especially ultrafine particles, upregulated TH cytokine levels, IgE production, and allergic a

SUBMITTER: Xia M 

PROVIDER: S-EPMC4530027 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature