Losartan treatment attenuates tumor-induced myocardial dysfunction.

ABSTRACT:

Unlabelled

Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patients. In clinical studies, inhibitors of angiotensin converting enzyme (ACE) can prevent the development of chemotherapy-induced cardiovascular dysfunction, suggesting a mechanistic role for the renin-angiotensin-aldosterone system (RAAS). In the present study, we investigated whether an angiotensin (AT) 1-receptor antagonist could prevent the development of tumor-associated myocardial dysfunction.

Methods and results

Colon26 adenocarcinoma (c26) cells were implanted into fema

SUBMITTER: Stevens SC 

PROVIDER: S-EPMC4530048 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature