TH9 cells are required for tissue mast cell accumulation during allergic inflammation.

ABSTRACT:

Background

IL-9 is important for the growth and survival of mast cells. IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and innate lymphoid cells, although the cells required for mast cell accumulation during allergic inflammation remain undefined.

Objective

We sought to elucidate the role of TH9 cells in promoting mast cell accumulation in models of allergic lung inflammation.

Methods

Adoptive transfer of ovalbumin-specific TH2 and TH9 cells was used to assess the ability of each subset to mediate mast cell accumulation in tissues. Mast cell accumulation was assessed in wild-type mice and mice with PU.1-deficient T cells subjected to acute and chronic models of allergic inflammation.

Results

Adoptive transfer experiments demonstra

SUBMITTER: Sehra S 

PROVIDER: S-EPMC4530056 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature