Measuring the corticosteroid responsiveness endophenotype in asthmatic patients.

ABSTRACT:

Background

Inhaled corticosteroids are the most commonly used controller therapies for asthma, producing treatment responses in 6 clinical phenotypes: lung function, bronchodilator response, airway responsiveness, symptoms, need for oral steroids and frequency of emergency department visits and hospitalizations. We hypothesize that treatment response in all of these phenotypes is modulated by a single quantitative corticosteroid responsiveness endophenotype.

Objective

We sought to develop a composite phenotype that combines multiple clinical phenotypes to measure corticosteroid responsiveness with high accuracy, stability across populations, and robustness to missing data.

Methods

We used principal component analysis to determine a composite corticosteroid responsiven

SUBMITTER: Clemmer GL 

PROVIDER: S-EPMC4530065 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature