Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.

ABSTRACT: Acute lung injury (ALI) is an acute inflammatory lung disease that causes morbidity and mortality in critically ill patients. However, there are many instances where ALI resolves spontaneously through endogenous pathways that help to control excessive lung inflammation. Previous studies have implicated the extracellular signaling molecule adenosine and signaling events through the A2B adenosine receptor in lung protection. In this context, we hypothesized that tissue-specific expression of the A2B adenosine receptor is responsible for the previously described attenuation of ALI. To address this hypothesis, we exposed mice with tissue-specific deletion of Adora2b to ALI, utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation. Interestingl

SUBMITTER: Hoegl S 

PROVIDER: S-EPMC4530072 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature