Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma.

ABSTRACT:

Background

The mechanisms underlying glucocorticoid responsiveness are largely unknown. Although redox regulation of the glucocorticoid receptor (GR) has been reported, it has not been studied in asthmatic patients.

Objective

We characterized systemic cysteine oxidation and its association with inflammatory and clinical features in healthy children and children with difficult-to-treat asthma. We hypothesized that cysteine oxidation would be associated with increased markers of oxidative stress and inflammation, increased features of asthma severity, decreased clinically defined glucocorticoid responsiveness, and impaired GR function.

Methods

PBMCs were collected from healthy children (n = 16) and children with asthma (n = 118) aged 6 to 17 years. Children with difficu

SUBMITTER: Stephenson ST 

PROVIDER: S-EPMC4530082 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature