MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis.

ABSTRACT:

Objectives

MUTYH glycosylase involved in DNA repair pathways may be associated with the risk of autoimmune diseases such as rheumatoid arthritis (RA). Therefore, the association between polymorphisms in the MUTYH gene and RA was evaluated.

Methods

We recruited 192 RA patients and 192 healthy subjects in Taiwan. The 4 MUTYH polymorphisms (rs3219463, rs3219476, rs3219489, and rs3219493) were detected and haplotype analysis was performed using the Bayesian method. The genotype and allelic frequency distributions of the polymorphisms in both RA patients and healthy patients were compared by the chi-square test.

Results

Comparison of the genotype/allele frequencies between individuals with RA and the control groups revealed significant differences in 2 MUTYH gene polymorph

SUBMITTER: Kung YJ 

PROVIDER: S-EPMC4530216 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature