Gene Coexpression and Evolutionary Conservation Analysis of the Human Preimplantation Embryos.

ABSTRACT: Evolutionary developmental biology (EVO-DEVO) tries to decode evolutionary constraints on the stages of embryonic development. Two models--the "funnel-like" model and the "hourglass" model--have been proposed by investigators to illustrate the fluctuation of selective pressure on these stages. However, selective indices of stages corresponding to mammalian preimplantation embryonic development (PED) were undetected in previous studies. Based on single cell RNA sequencing of stages during human PED, we used coexpression method to identify gene modules activated in each of these stages. Through measuring the evolutionary indices of gene modules belonging to each stage, we observed change pattern of selective constraints on PED for the first time. The selective pressure decreases from the zyg

SUBMITTER: Liu T 

PROVIDER: S-EPMC4530217 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature