NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients.

ABSTRACT:

Background

It is generally accepted that poor glycemic control, arterial hypertension and/or hyperlipidemia, and the associated oxidative stress may contribute to the development of macro- and microvascular complications in type 2 diabetes (T2D). Such metabolic damage signals may activate inflammasome and trigger chronic inflammation. We investigated common polymorphisms in inflammasome coding genes and the risk for macro- and microvascular complications in T2D.

Methods

In total 181 clinically well-characterised T2D patients were genotyped for NLRP3 rs35829419 and CARD8 rs2043211. Risk for diabetic complications was assessed using logistic regression.

Results

Patients with median duration of T2D 11 (6-17) years had relatively well controlled blood glucose and lipid le

SUBMITTER: Klen J 

PROVIDER: S-EPMC4530261 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature