Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.

ABSTRACT: We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.

SUBMITTER: Kikuta S 

PROVIDER: S-EPMC4530460 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature