Ontology highlight
ABSTRACT:
SUBMITTER: Egan DF
PROVIDER: S-EPMC4530630 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20150625 2
Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway and thus represents an excellent drug target. Despite recent advances in the understanding of ULK1 activation by nutrient deprivation, how ULK1 promotes autophagy remains poorly understood. Here, we screened degenerate peptide libraries to deduce the optimal ULK1 substrate motif and ...[more]