Area-specific information processing in prefrontal cortex during a probabilistic inference task: a multivariate fMRI BOLD time series analysis.

ABSTRACT:

Introduction

Discriminating spatiotemporal stages of information processing involved in complex cognitive processes remains a challenge for neuroscience. This is especially so in prefrontal cortex whose subregions, such as the dorsolateral prefrontal (DLPFC), anterior cingulate (ACC) and orbitofrontal (OFC) cortices are known to have differentiable roles in cognition. Yet it is much less clear how these subregions contribute to different cognitive processes required by a given task. To investigate this, we use functional MRI data recorded from a group of healthy adults during a "Jumping to Conclusions" probabilistic reasoning task.

Methods

We used a novel approach combining multivariate test statistics with bootstrap-based procedures to discriminate between different task st

SUBMITTER: Demanuele C 

PROVIDER: S-EPMC4530897 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature