Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction.

ABSTRACT: Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls

SUBMITTER: Park JY 

PROVIDER: S-EPMC4530944 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature