Aggregation of MBP in chronic demyelination.

ABSTRACT:

Objectives

Misfolding of key disease proteins to an insoluble state is associated with most neurodegenerative conditions, such as prion, Parkinson, and Alzheimer's diseases. In this work, and by studying animal models of multiple sclerosis, we asked whether this is also the case for myelin basic protein (MBP) in the late and neurodegenerative phases of demyelinating diseases.

Methods

To this effect, we tested whether MBP, an essential myelin component, present prion-like properties in animal models of MS, as is the case for Cuprizone-induced chronic demyelination or chronic phases of Experimental Autoimmune Encephalomyelitis (EAE).

Results

We show here that while total levels of MBP were not reduced following extensive demyelination, part of these molecules accumulate

SUBMITTER: Frid K 

PROVIDER: S-EPMC4531054 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature