Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster.

ABSTRACT: Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, suggest that it is the intake of specific nutrients that extends LS and mediates this trade-off. Here, we used the geometric framework (GF) to examine the sex-specific effects of protein (P) and carbohydrate (C) intake on LS and reproduction in Drosophila melanogaster. We found that LS was maximized at a high intake of C and a low intake of P in both sexes, whereas nutrient intake had divergent effects on reproduction. Male offspring production rate and LS were maximized at th

SUBMITTER: Jensen K 

PROVIDER: S-EPMC4531074 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature