Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis.

ABSTRACT:

Background

Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls, taken from macroscopically noninflamed tissue from the terminal ileum and 3 colonic locations with the objective of identifying abnormal molecules that might be involved in disease development.

Methods

Whole-genome transcriptional analysis was performed on intestinal biopsies taken from 24 patients with UC, 26 healthy controls, and 14 patients with Crohn's disease. Differential gene expression analysis was performed at each tissue location separately, and results were then meta-analyzed. Significantly, differentially expressed genes were validat

SUBMITTER: Smith PJ 

PROVIDER: S-EPMC4531309 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature