The Effect of Body Position on Physiological Factors that Contribute to Obstructive Sleep Apnea.

ABSTRACT:

Study objectives

Obstructive sleep apnea (OSA) resolves in lateral sleep in 20% of patients. However, the effect of lateral positioning on factors contributing to OSA has not been studied. We aimed to measure the effect of lateral positioning on the key pathophysiological contributors to OSA including lung volume, passive airway anatomy/collapsibility, the ability of the airway to stiffen and dilate, ventilatory control instability (loop gain), and arousal threshold.

Design

Non-randomized single arm observational study.

Setting

Sleep laboratory.

Patients/participants

20 (15M, 5F) continuous positive airway pressure (CPAP)-treated severe OSA patients.

Interventions

Supine vs. lateral position.

Measurements

CPAP dial-downs performed during sleep to

SUBMITTER: Joosten SA 

PROVIDER: S-EPMC4531415 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature