MultiSETTER: web server for multiple RNA structure comparison.

ABSTRACT:

Background

Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm.

Results

In this paper, w

SUBMITTER: Cech P 

PROVIDER: S-EPMC4531852 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature