Design of non-pharmaceutical intervention strategies for pandemic influenza outbreaks.

ABSTRACT:

Background

As seen during past pandemic influenza outbreaks, pharmaceutical interventions (PHIs) with vaccines and antivirals are the most effective methods of mitigation. However, availability of PHIs is unlikely to be adequate during the early stages of a pandemic. Hence, for early mitigation and possible containment, non-pharmaceutical interventions (NPIs) offer a viable alternative. Also, NPIs may be the only available interventions for most underdeveloped countries. In this paper we present a comprehensive methodology for design of effective NPI strategies.

Methods

We develop a statistical ANOVA-based design approach that uses a detailed agent-based simulation as an underlying model. The design approach obtains the marginal effect of the characteristic parameters of NPI

SUBMITTER: Martinez DL 

PROVIDER: S-EPMC4532250 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature