The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis.

ABSTRACT:

Background

Haemophilus parasuis is the etiologic agent of Glässer's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype.

Results

Recombination and population structure analyses identified five groups with very high rates of recombination, separated into two clades of H. parasuis with no signs of recombination between them. We used genome-wide associatio

SUBMITTER: Howell KJ 

PROVIDER: S-EPMC4532294 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature