Survival among people with Down syndrome: a nationwide population-based study in Denmark.

ABSTRACT:

Purpose

Several studies have shown substantially longer survival among persons with Down syndrome in recent decades. We examined survival patterns among Danish persons with Down syndrome by karyotype.

Methods

A national cohort of 3,530 persons with Down syndrome identified from the Danish Cytogenetic Register and a reference cohort of persons without Down syndrome randomly selected from the general population were followed from 1 April 1968 to 15 January 2009 by linkages to the Register of Causes of Death and the Civil Registration System.

Results

Overall, persons with Down syndrome had higher mortality than the reference cohort but to a lesser degree for persons with mosaic trisomy 21 than for persons with standard trisomy 21 or with Robertsonian translocations (haza

SUBMITTER: Zhu JL 

PROVIDER: S-EPMC4532298 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature