New gene variants associated with venous thrombosis: a replication study in White and Black Americans.

ABSTRACT:

Background

We evaluated 10 single-nucleotide polymorphisms (SNPs) identified in three European case-control studies as risk factors for venous thrombosis.

Objectives

We sought to replicate the positive findings from this report among Whites and to evaluate the association of these SNPs with venous thrombosis for the first time among Blacks.

Patient/methods

These SNPs were evaluated in a case-control study of deep vein thrombosis and pulmonary embolism that included 1076 cases and 1239 controls. About 50% of subjects were African Americans. We measured plasma factor (F) XI on a subset of subjects.

Results

Among Whites, positive findings for rs13146272 in the CYP4V2 gene, for rs3087505 in the KLKB1 gene and for rs3756008 and rs2036914 in the F11 gene were found.

SUBMITTER: Austin H 

PROVIDER: S-EPMC4532311 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature