The role of systemic chemotherapy in the management of granulosa cell tumors.

ABSTRACT:

Objective

Granulosa cell tumors (GCTs) are rare, and the role of chemotherapy in their management is not clearly defined.

Methods

We performed a retrospective cohort study of GCT patients diagnosed from January 1996 through June 2013 at the Memorial Sloan Kettering Cancer Center, comparing those who received adjuvant chemotherapy to those who did not. Differences between groups were assessed using the log-rank test. Statistical significance was set at p<0.05.

Results

Of 118 patients, 10 (8%) received adjuvant chemotherapy (1 [1%] of 103 stage I and 9 [60%] of 15 stage II-IV patients). Thirty-two patients (27%) experienced disease recurrence. Four patients had residual disease after initial surgery, and all received adjuvant chemotherapy; each recurred within 24.3 mont

SUBMITTER: Meisel JL 

PROVIDER: S-EPMC4532352 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature