Structure-Based Phylogenetic Analysis of the Lipocalin Superfamily.

ABSTRACT: Lipocalins constitute a superfamily of extracellular proteins that are found in all three kingdoms of life. Although very divergent in their sequences and functions, they show remarkable similarity in 3-D structures. Lipocalins bind and transport small hydrophobic molecules. Earlier sequence-based phylogenetic studies of lipocalins highlighted that they have a long evolutionary history. However the molecular and structural basis of their functional diversity is not completely understood. The main objective of the present study is to understand functional diversity of the lipocalins using a structure-based phylogenetic approach. The present study with 39 protein domains from the lipocalin superfamily suggests that the clusters of lipocalins obtained by structure-based phylogeny correspond w

SUBMITTER: Lakshmi B 

PROVIDER: S-EPMC4532494 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature