Ontology highlight
ABSTRACT:
SUBMITTER: Chen HJ
PROVIDER: S-EPMC4532544 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nature biotechnology 20150525 6
Current orthotopic xenograft models of human colorectal cancer (CRC) require surgery and do not robustly form metastases in the liver, the most common site clinically. CCR9 traffics lymphocytes to intestine and colorectum. We engineered use of the chemokine receptor CCR9 in CRC cell lines and patient-derived cells to create primary gastrointestinal (GI) tumors in immunodeficient mice by tail-vein injection rather than surgery. The tumors metastasize inducibly and robustly to the liver. Metastase ...[more]