Molecular changes in endometriosis-associated ovarian clear cell carcinoma.

ABSTRACT:

Background

Endometriosis is frequently associated with and thought of having propensity to develop into ovarian clear cell carcinoma (OCCC), although the molecular transformation mechanism is not completely understood.

Methods

We employed immunohistochemical (IHC) staining for marker expression along the potential progression continuum. Expression profiling of microdissected endometriotic and OCCC cells from patient-matched formalin-fixed, paraffin-embedded samples was performed to explore the carcinogenic pathways. Function of novel biomarkers was confirmed by knockdown experiments.

Results

PTEN was significantly lost in both endometriosis and invasive tumour tissues, while oestrogen receptor (ER) expression was lost in OCCC relative to endometriosis. XRCC5, PTCH2, e

SUBMITTER: Worley MJ 

PROVIDER: S-EPMC4532605 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature