Extracts from presumed "reduced harm" cigarettes induce equivalent or greater toxicity in antigen-presenting cells.

ABSTRACT: The tobacco industry has promoted certain cigarette products with claims that their use may be less harmful to the smoker as they purportedly deliver lower amounts of toxic chemicals compared to conventional cigarettes. This study was designed to compare the relative antigen presenting cellular toxicity of Eclipse, a presumed reduced exposure product (PREP) cigarette, when compared with the reference research 3R4F cigarettes (Kentucky University). Utilizing a murine macrophage cell line, murine bone marrow derived dendritic cells (DCs) and human monocyte-derived DCs incubated with extracts generated from Eclipse and Kentucky reference 3R4F cigarettes, we determined the relative toxic effects of the different cigarette smoke extracts on cellular viability, oxidative stress, T-helper-1 (Th-1

SUBMITTER: Vassallo R 

PROVIDER: S-EPMC4532619 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature