Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle.

ABSTRACT: Despite extensive study over the past six decades the coupling of chemical reaction and mechanical processes in muscle dynamics is not well understood. We lack a theoretical description of how chemical processes (metabolite binding, ATP hydrolysis) influence and are influenced by mechanical processes (deformation and force generation). To address this need, a mathematical model of the muscle cross-bridge (XB) cycle based on Huxley's sliding filament theory is developed that explicitly accounts for the chemical transformation events and the influence of strain on state transitions. The model is identified based on elastic and viscous moduli data from mouse and rat myocardial strips over a range of perturbation frequencies, and MgATP and inorganic phosphate (Pi) concentrations. Simulations o

SUBMITTER: Tewari SG 

PROVIDER: S-EPMC4532654 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature