Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults.

ABSTRACT:

Objective

Subjective cognitive complaints in otherwise normal aging are common but may be associated with preclinical Alzheimer disease in some individuals. Little is known about who is mostly likely to show associations between cognitive complaints and preclinical Alzheimer pathology. We sought to demonstrate associations between subjective complaints and brain amyloid-β in cognitively normal older adults; and to explore personality factors as potential moderators of this association.

Design

Cross-sectional observational study.

Setting

Clinical neuroimaging research center.

Participants

Community volunteer sample of 92 healthy older adults, screened for normal cognition with comprehensive neuropsychological evaluation.

Measurements

Subjective cognitive

SUBMITTER: Snitz BE 

PROVIDER: S-EPMC4532656 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature