Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation.

ABSTRACT: Conservation of a patient's residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in cochlear implant (CI) surgery. Although it is well-known that fibrotic tissue formation around the electrode array can interfere with hearing performance in implanted patients, and that associated intracochlear inflammation can initiate loss of residual hearing, little is known about the molecular and cellular mechanisms that promote this response in the cochlea. In vitro studies in neonatal rats and in vivo studies in adult mice were performed to gain insight into the pro-inflammatory, proliferative, and remodeling phases of pathological wound healing that occur in the cochlea following an electrode analog insertion. Resident Schwan

SUBMITTER: Bas E 

PROVIDER: S-EPMC4532929 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature