Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation.

ABSTRACT: Strategies for harnessing stem cells as a source to treat cell loss in heart disease are the subject of intense research. Human pluripotent stem cells (hPSCs) can be expanded extensively in vitro and therefore can potentially provide sufficient quantities of patient-specific differentiated cardiomyocytes. Although multiple stimuli direct heart development, the differentiation process is driven in large part by signaling activity. The engineering of hPSCs to heart cell progeny has extensively relied on establishing proper combinations of soluble signals, which target genetic programs thereby inducing cardiomyocyte specification. Pertinent differentiation strategies have relied as a template on the development of embryonic heart in multiple model organisms. Here, information on the regulatio

SUBMITTER: Parikh A 

PROVIDER: S-EPMC4533091 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature